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Sialate O-acetylesterase (SIAE) is a protein that in human is encoded by the SIAE gene located on chromosome 11. The SIAE protein functions in carbohydrate metabolism and catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid. == Strcuture == The SIAE gene contains 15 exons 〔http://www.ncbi.nlm.nih.gov/gene/54414〕 and expresses a protein that is approximately 56 kDa in size. It is known to be expressed in the adult testis. == Function == SIAE activity negatively regulates B lymphocyte antigen receptor signalling and is required for the maintenance of immunological tolerance. In enzymology, a sialate O-acetylesterase () is an enzyme that catalyzes the chemical reaction :N-acetyl-O-acetylneuraminate + H2O N-acetylneuraminate + acetate Thus, the two substrates of this enzyme are N-acetyl-O-acetylneuraminate and H2O, whereas its two products are N-acetylneuraminate and acetate. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sialate O-acetylesterase」の詳細全文を読む スポンサード リンク
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